Researchers at Georgia State University have developed an experimental oral antiviral, GHP-88310, which successfully blocked measles-like virus transmission in ferrets through both close contact and airborne routes.

The drug, a broad-spectrum inhibitor of the viral polymerase, reduced symptoms and shortened the contagious period when administered before or after exposure.Published in Nature Microbiology, the study focused on canine distemper virus, which mimics measles in ferrets.The findings suggest the antiviral could complement traditional vaccination strategies to control outbreaks.

Measles has reemerged in North America since 2025, causing significant infections and deaths, prompting concerns about maintaining elimination status.The drug's ability to prevent airborne transmission in a ferret model is unprecedented for viral polymerase inhibitors.Researchers are preparing for clinical trials, with support from the National Institutes of Health.The study highlights potential benefits for reducing quarantine burdens and improving outbreak management.